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Kristina Rinker is the Director of the Centre for Bioengineering Research and Education and an associate professor in the Schulich School of Engineering's Department of Chemical and Petroleum Engineering and the Cumming School of Medicine's Department of Physiology and Pharmacology.
Kristina's research focuses on how fluid flow affects cell and nanoparticle behavior with relevance to cardiovascular disease, stem cells, and cancer. Her research group has developed new tools for use in physiological profiling of cells, drug target/biomarker identification, tissue engineering, and the screening of pharmaceuticals, nanoparticles and MRI contrast agents.
- Jiang, X.-Y., C.D. Sarsons, M.J. Gomez-Garcia, D.T. Cramb, K.D. Rinker, S.J. Childs. 2016. Quantum dot interactions and flow effects in angiogenic zebrafish (Danio rerio) vessels and human endothelial cells. Nanomedicine: Nanotechnology, Biology, and Medicine, xx:1-12, http://dx.doi.org/10.1016/j.nano.2016.12.008
- Sykes, E.A., Q. Dai, C. Sarsons, J. Chen, J. V. Rochleau, D. I. Hwang, G. Zheng, D. Cramb, K. D. Rinker, W. C. W. Chan. 2016. Tailoring nanoparticle designs to target cancer based on tumor pathophysiology. Proceedings of the National Academy of Sciences, 113(9): E1142-E1151.
- Sarsons, C., A. Tekrony, Yaehne, K., S. Childs, K.D. Rinker, D. Cramb. 2014. Testing Nanoparticles for Angiogenesis-Related Disease: Charting the Fastest Route to the Clinic. Journal of Biomedical Nanotechnology, 10:1641-1676.
- Lara, G., O. Hazenbiller, T. Gareau, R. D. Shepherd, M. Kallos, D. Rancourt, K.D. Rinker. 2013. Fluid flow modulation of murine embryonic stem cell pluripotency gene expression in the absence of LIF. Cell and Molecular Bioengineering, 2013, 6(3): 335-345.
- Tekrony, A., K. Yaehne, A. Clancy, Y. Gregoriou, J. Walker, T. Nguyen, A. Doiron, K. Rinker, S. Jiang, S. Childs, D. Cramb. 2013. Nanoparticle accumulation in angiogenic tissues: Towards predictable pharmacokinetics. Small, 9(18): 3006-3127.
- Gareau T, Lara G, Shepherd RD, Taiani J, Krawetz R, Rancourt D, Rinker KD, Kallos MS. 2012. Shear stress influences pluripotency of murine Embryonic Stem Cells (mESCs) in suspension bioreactors. Journal of Tissue Engineering and Regenerative Medicine, 8(4):268-78. DOI: 10.1002/term.1518.
- Doiron, A., B. Clark, K.D. Rinker. 2011. Endothelial nanoparticle binding kinetics are matrix and size dependent. Biotechnology and Bioengineering, 108(12):2988-2998.
- Shepherd, R.D., S.M. Kos, and K.D. Rinker. 2011. Flow dependent Smad2 phosphorylation and TGIF nuclear localization in human aortic endothelial cells, American Journal of Physiology: Heart and Circulatory Physiology, 301(1):H98-H107.
- Viegas, K.D., M. Mehdi, S. Dol, R.D. Shepherd, R. Martinuzzi, and K.D. Rinker. 2011. Methicillin Resistant Staphylococcus aureus attachment to endothelium is wall shear stress dependent. BioMedical Engineering OnLine, 10:20.
- Aulanier, A.L., A.L. Doiron, R.D. Shepherd, K.D. Rinker, R. Frayne, L.B. Andersen. 2011. Human endothelial-monocyte cell model for testing of targeting agents for detection of early atherosclerosis by Magnetic Resonance Imaging. BioTechniques, 50:120-123.
- Shepherd, R.D., S.M. Kos, and K.D. Rinker. 2009. Long-term pulsatile shear stress leads to increased phosphorylation of multiple MAPK species in cultured human aortic endothelial cells. Biorheology. 46(6): 529-538.